Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi; In Cheol Sun; Ju Hee Ryu; Heebeom Koo; Chul Wan Park; In Chan Youn; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1021/bc100308p

Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi
, In Cheol Sun
, Ju Hee Ryu
, Heebeom Koo
, Chul Wan Park
, In Chan Youn
, Kuiwon Choi
, Ick Chan Kwon
, Kwangmeyung Kim
, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

Original language	English
Pages (from-to)	2173-2177
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	21
Issue number	12
DOIs	https://doi.org/10.1021/bc100308p
State	Published - 15 Dec 2010

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SDG 3 Good Health and Well-being

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10.1021/bc100308p

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title = "Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer",

abstract = "Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.",

author = "Yi, \{Dong Kee\} and Sun, \{In Cheol\} and Ryu, \{Ju Hee\} and Heebeom Koo and Park, \{Chul Wan\} and Youn, \{In Chan\} and Kuiwon Choi and Kwon, \{Ick Chan\} and Kwangmeyung Kim and Ahn, \{Cheol Hee\}",

year = "2010",

month = dec,

day = "15",

doi = "10.1021/bc100308p",

language = "English",

volume = "21",

pages = "2173--2177",

journal = "Bioconjugate Chemistry",

issn = "1043-1802",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

AU - Yi, Dong Kee

AU - Sun, In Cheol

AU - Ryu, Ju Hee

AU - Koo, Heebeom

AU - Park, Chul Wan

AU - Youn, In Chan

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

AB - Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

UR - https://www.scopus.com/pages/publications/78650336753

U2 - 10.1021/bc100308p

DO - 10.1021/bc100308p

M3 - Article

C2 - 21062090

AN - SCOPUS:78650336753

SN - 1043-1802

VL - 21

SP - 2173

EP - 2177

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 12

ER -

Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Abstract

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