Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi; In Cheol Sun; Ju Hee Ryu; Heebeom Koo; Chul Wan Park; In Chan Youn; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1021/bc100308p

Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi, In Cheol Sun, Ju Hee Ryu, Heebeom Koo, Chul Wan Park, In Chan Youn, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

Original language	English
Pages (from-to)	2173-2177
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	21
Issue number	12
DOIs	https://doi.org/10.1021/bc100308p
State	Published - 15 Dec 2010

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10.1021/bc100308p

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title = "Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer",

abstract = "Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.",

author = "Yi, {Dong Kee} and Sun, {In Cheol} and Ryu, {Ju Hee} and Heebeom Koo and Park, {Chul Wan} and Youn, {In Chan} and Kuiwon Choi and Kwon, {Ick Chan} and Kwangmeyung Kim and Ahn, {Cheol Hee}",

year = "2010",

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doi = "10.1021/bc100308p",

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TY - JOUR

T1 - Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

AU - Yi, Dong Kee

AU - Sun, In Cheol

AU - Ryu, Ju Hee

AU - Koo, Heebeom

AU - Park, Chul Wan

AU - Youn, In Chan

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

AB - Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

UR - http://www.scopus.com/inward/record.url?scp=78650336753&partnerID=8YFLogxK

U2 - 10.1021/bc100308p

DO - 10.1021/bc100308p

M3 - Article

C2 - 21062090

AN - SCOPUS:78650336753

SN - 1043-1802

VL - 21

SP - 2173

EP - 2177

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 12

ER -

Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Abstract

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