Maternal stress and depressive symptoms and infant development at six months: The mothers and children's environmental health (MOCEH) prospective study

Soo Young Bhang, Eunhee Ha, Hyesook Park, Mina Ha, Yun Chul Hong, Boong Nyun Kim, Soo Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Joseph Jeong, Kyoung Sook Jeong, Boeun Lee, Yangho Kim

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Our objective is to evaluate the relationships between prenatal maternal stress and depressive symptoms, respectively, and infant neurodevelopment at 6 months, adjusted for heavy metals and oxidative stress. This research is a part of a multi-center birth cohort study in South Korea. Information on stress and depressive symptoms was collected during the first trimester using Psychosocial Well-Being Index Short Form (PWI-SF) and Center for Epidemiological Studies Depression Scale (CES-D). The Korean Bayley Scales of Infant Development-II assessment (BSID-II), which includes the standardized mental development index (MDI) and psychomotor developmental index (PDI), and Korean Ages & Stages Questionnaires (K-ASQ) were applied to infants at six months of age. A higher index score indicates better development. Among 641 babies, 320 were female (50%). Maternal PWI ≥ 29 (vs. PWI ≤ 18) during early pregnancy was associated with a decrease in MDI scores of 5.37 points (P = 0.02) after adjusting for socioeconomic factors. Maternal CES-D ≥ 26 (vs. CES-D ≤ 10) during early pregnancy was associated with a decrease in MDI scores of 8.18 points (P = 0.01). The associations remained significant even after adjustment for lead, cadmium, and MDA levels (P < 0.05). However, no association was found between maternal PWI/CES-D and PDI score. No interaction was observed between stress and lead exposure. We found an inverse association between prenatal maternal stress and depressive symptoms, and MDI scores in 6-month-old infants after adjustment for prenatal lead exposure, which is known to affect cognitive function negatively.

Original languageEnglish
Pages (from-to)843-851
Number of pages9
JournalJournal of Korean Medical Science
Volume31
Issue number6
DOIs
StatePublished - 1 Jun 2016

Keywords

  • Antenatal stress
  • Cadmium
  • Cognitive development
  • Depression
  • Lead
  • Malondialdehyde
  • Oxidation

Fingerprint

Dive into the research topics of 'Maternal stress and depressive symptoms and infant development at six months: The mothers and children's environmental health (MOCEH) prospective study'. Together they form a unique fingerprint.

Cite this