Markers in morphine- and cocaine-addicted animals

Zhenzhen Hu, Kwang Soon Park, Jin Yi Han, Choon Gon Jang, Seikwan Oh, Hyoung Chun Kim, Chae Ha Yang, Eun Jeong Kim, Ki Wan Oh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


These experiments were designed to use typical makers from behaviors and molecular basis in addicted animals of morphine and cocaine. Morphine has been widely abused with a high physical dependence liability. Morphine withdrawal activates the intracellular cAMP signaling pathway and further leads to changes in the expression of the cAMP response element binding protein (CREB), which may be important to the development and expression of morphine dependence. From these experiments, repeated morphine (10 mg/kg, twice per day for 7 days) developed physical dependence. Withdrawal signs were precipitated by naloxone and also increased the expression of the CREB. In addition, repeated exposure of cocaine (15 mg/kg) to mice develops locomotor sensitization and produced lasting behavioral sensitivity. Cocaine- and amphetamine-regulated transcript peptide (CART) peptide was up-regulated by repeated administration of cocaine in the striatum. Therefore, repeated morphine induced the development of physical dependence and increased pCREB. In addition, repeated cocaine induced locomotor sensitization and over-expressed CART peptide. In conclusion, the development of physical dependence and pCREB for morphine, and locomotor sensitization and CART peptide over-expression for cocaine would be useful markers to predict the abuse potential of opioid analgesics and pychostimulant drugs in animals, respectively.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalBiomolecules and Therapeutics
Issue number1
StatePublished - Jan 2011


  • Addiction
  • CART
  • Cocaine
  • Marker
  • Morphine
  • pCREB


Dive into the research topics of 'Markers in morphine- and cocaine-addicted animals'. Together they form a unique fingerprint.

Cite this