Marine natural products with monoamine oxidase (MAO) inhibitory activity

Ahreum Hong, Le Cam Tu, Inho Yang, Kyung Min Lim, Sang Jip Nam

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Context: Research interest in monoamine oxidase (MAO) as a promising drug target for neurodegenerative diseases has a long history. However, efforts to develop MAO inhibitors (MAOIs) from marine sources have been limited, despite the increasing number of interesting marine natural products. Objective: To review the potential of marine natural products as MAOIs source, including their activities and selectivity on MAO. Methods: Public databases such as SciFinder, MarinLit and PubMed were systematically searched from 1991 until Dec 2019. MAO and MAOI were the key terms searched combined with marine natural products and marine. Results: Six classes of marine natural products with good selectivity between the two MAO subtypes were organized with their selectivity and sources. Conclusions: This is the first review to investigate the potential of marine natural products as MAOIs source. Despite the small number of known MAOIs from marine sources, marine natural products are potential leads for the further development of MAOI drugs with novel chemical frames and good selectivity.

Original languageEnglish
Pages (from-to)716-720
Number of pages5
JournalPharmaceutical Biology
Volume58
Issue number1
DOIs
StatePublished - 1 Jan 2020

Keywords

  • anithiactins
  • aplysinopsins
  • astaxanthin
  • bromopyrroles
  • caulerpins
  • MAOIs
  • piloquinones

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