Marine mudflat actinomycetes as a novel natural products source

Dohee Ryu, Prima F. Hillman, Ganiyu Akinniyi, Sang Jip Nam, Inho Yang

Research output: Contribution to journalReview articlepeer-review


A mudflat is a type of intertidal zone that is alternately affected by terrestrial and marine environments. We searched for examples of research related to the discovery of secondary metabolites in actinomycetes originating from mudflats. In total, we found 16 studies describing 42 natural products. The recognized bioactivities of the secondary metabolites were digested. We also performed a phylogenetic analysis of mudflat-derived actinomycetes. Most of the actinomycete strains belong to the genus Streptomyces. This review underscores mudflat as promising environment for discovering novel actinomycete strains that produce unique bioactive secondary metabolites. This highlights the imperative to explore this distinct environment for marine natural product research.

Original languageEnglish
Article number1297446
JournalFrontiers in Marine Science
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Ryu, Hillman, Akinniyi, Nam and Yang.


  • intertidal actinomycetes
  • marine actinomycetes
  • marine microbial secondary metabolites
  • marine natural products
  • tidal actinomycetes
  • tidal flat actinomycetes


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