@article{1fe837b47d984124aae46a8e78f2db39,
title = "Marine Depsipeptide Nobilamide i Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression",
abstract = "A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in 1 were assigned by using the C3 Marfey's analysis and comparing them with those of 2 based on their biosynthetic pathways. Nobilamide I (1) decreased cell motility by inhibiting epithelial-mesenchymal transition markers in A549 (lung cancer), AGS (gastric cancer), and Caco2 (colorectal cancer) cell lines. In addition, 1 modulated the expression of the matrix metalloproteinase (MMP) family (MMP2 and MMP9) in the three cell lines.",
author = "Le, {Tu Cam} and Sultan Pulat and Jihye Lee and Kim, {Geum Jin} and Haerin Kim and Lee, {Eun Young} and Hillman, {Prima F.} and Hyukjae Choi and Inho Yang and Oh, {Dong Chan} and Hangun Kim and Nam, {Sang Jip} and William Fenical",
note = "Funding Information: This work was funded by National Research Foundation of Korea Grants funded by the Korean Government (Ministry of Science and ICT) (Nos. 2021R1A4A2001251 to S.-J.N.), and by Basic Science Research Program through the National Research Foundation of Korea (NRF-2020R1C1C1007832 to H.K.) and supported by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2020R 1A 6C 101B194). Isolation of the strain was a result of financial support from the US National Cancer Institute under grant CA R37044848 (to W.F.). Publisher Copyright: {\textcopyright} 2022 The Authors. Published by American Chemical Society.",
year = "2022",
month = jan,
day = "18",
doi = "10.1021/acsomega.1c04520",
language = "English",
volume = "7",
pages = "1722--1732",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "American Chemical Society",
number = "2",
}