Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: A preliminary study

Chi Un Pae, Su Jung Yoon, Ashwin Patkar, Jung Jin Kim, Tae Youn Jun, Chul Lee, In Ho Paik

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21 Scopus citations


This study examined the relationship between a MnSOD gene (MnSOD) polymorphism (Ala-9Val) and mood disorders such as major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with BD, 61 patients with MDD and 106 healthy controls were enrolled in this study and genotyped using a polymerase chain reaction-based method. The patients with MDD and BD, and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD polymorphism and mood disorders. Subgroup analyses according to the clinical variables such as the family history, age at onset, psychotic features and suicide history failed to identify any association with the Ala-9Val MnSOD polymorphism. This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed.

Original languageEnglish
Pages (from-to)1326-1329
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number7
StatePublished - 30 Sep 2006

Bibliographical note

Funding Information:
This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050047).


  • Bipolar I disorder
  • Korean
  • Major depressive disorder
  • Manganese superoxide dismutase
  • Polymorphism


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