TY - JOUR
T1 - Making the Brightest Ones Dim
T2 - Maximizing the Photothermal Conversion Efficiency of BODIPY-Based Photothermal Agents
AU - Kim, Gibeom
AU - Luo, Yongyang
AU - Shin, Myunghwan
AU - Bouffard, Jean
AU - Bae, Jeehyeon
AU - Kim, Youngmi
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/7/26
Y1 - 2024/7/26
N2 - The successful implementation of photothermal therapy (PTT) in cancer treatment hinges on the development of highly effective photothermal agents (PTAs). Boron dipyrromethene (BODIPY) dyes, being well known for their high brightness and quantum efficiencies, are the antithesis of PTAs. Nonetheless, a systematic exploration of the photophysics and photothermal characteristics of a series of π-extended BODIPY dyes with high absorptivity in the near-infrared (NIR) region has achieved superior photothermal conversion efficiencies (>90%), in both monomeric state and nanoparticles after encapsulation in a biocompatible polyethyleneglycol 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethylene glycol)-2000]. Optimal PTA candidates combine strong NIR absorption provided by extended donor–acceptor conjugation and an optimization of the electronic and steric effects of meso-substituents to maximize photothermal conversion performance. The PTT-optimized meso-CF3-BODIPY, TCF3PEn exhibits exceptional efficacy in inducing cancer cell apoptosis and in vivo tumor ablation using low-power NIR laser irradiation (0.3 W cm−2, 808 nm) as well as excellent biological safety, underscoring its potential for advancing light-induced cancer therapies.
AB - The successful implementation of photothermal therapy (PTT) in cancer treatment hinges on the development of highly effective photothermal agents (PTAs). Boron dipyrromethene (BODIPY) dyes, being well known for their high brightness and quantum efficiencies, are the antithesis of PTAs. Nonetheless, a systematic exploration of the photophysics and photothermal characteristics of a series of π-extended BODIPY dyes with high absorptivity in the near-infrared (NIR) region has achieved superior photothermal conversion efficiencies (>90%), in both monomeric state and nanoparticles after encapsulation in a biocompatible polyethyleneglycol 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethylene glycol)-2000]. Optimal PTA candidates combine strong NIR absorption provided by extended donor–acceptor conjugation and an optimization of the electronic and steric effects of meso-substituents to maximize photothermal conversion performance. The PTT-optimized meso-CF3-BODIPY, TCF3PEn exhibits exceptional efficacy in inducing cancer cell apoptosis and in vivo tumor ablation using low-power NIR laser irradiation (0.3 W cm−2, 808 nm) as well as excellent biological safety, underscoring its potential for advancing light-induced cancer therapies.
KW - BODIPY dyes
KW - nonradiative decay
KW - photothermal agents
KW - photothermal conversion efficiency
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85190159634&partnerID=8YFLogxK
U2 - 10.1002/adhm.202400885
DO - 10.1002/adhm.202400885
M3 - Article
C2 - 38573765
AN - SCOPUS:85190159634
SN - 2192-2640
VL - 13
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 19
M1 - 2400885
ER -