TY - GEN
T1 - Magneto-nanosensor for sensitive detection of ovarian cancer antibody biomarker anti-Selenium-Binding Protein 1
AU - Gani, A.
AU - Edassery, S.
AU - Xu, L.
AU - Lee, J.
AU - Luborsky, J.
AU - Wang, S. X.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/7/14
Y1 - 2015/7/14
N2 - Autoantibody biomarker relatively recently gains a lot of research interest for early detection of cancer. Cancer autoantibody is an antibody produced by the host's immune system in response to tumor antigen. It is produced at a much earlier disease stage before other biomarkers can be observed, circulates in the serum for a relatively long period of time, and is present at higher concentrations than antigen biomarkers [1]. In addition to identifying the early antibody biomarker, early detection of cancer needs to be complemented by the availability of ultrasensitive and reliable detection platform. Magneto-Nanosensor is a robust biomolecular diagnostics platform that has been shown to have superior sensitivity and dynamic range compared to the current gold standard ELISA (Enzyme-linked Immunosorbent Assay) [2]. One potential antibody biomarker for the early detection of ovarian cancer is anti-Selenium-Binding Protein 1 (anti-SBP1, also known as anti-SELENBP1). Studies showed that concentration levels of SBP1 are associated with cancer progression [3]. This submission reports highly-sensitive and reliable detection of anti-SBP1 using magnetic immunoassay technique on Magneto-Nanosensor platform. The high sensitivity of our detection platform combined with the early antibody biomarker can serve as a powerful diagnostic tool for enabling early detection of ovarian cancer.
AB - Autoantibody biomarker relatively recently gains a lot of research interest for early detection of cancer. Cancer autoantibody is an antibody produced by the host's immune system in response to tumor antigen. It is produced at a much earlier disease stage before other biomarkers can be observed, circulates in the serum for a relatively long period of time, and is present at higher concentrations than antigen biomarkers [1]. In addition to identifying the early antibody biomarker, early detection of cancer needs to be complemented by the availability of ultrasensitive and reliable detection platform. Magneto-Nanosensor is a robust biomolecular diagnostics platform that has been shown to have superior sensitivity and dynamic range compared to the current gold standard ELISA (Enzyme-linked Immunosorbent Assay) [2]. One potential antibody biomarker for the early detection of ovarian cancer is anti-Selenium-Binding Protein 1 (anti-SBP1, also known as anti-SELENBP1). Studies showed that concentration levels of SBP1 are associated with cancer progression [3]. This submission reports highly-sensitive and reliable detection of anti-SBP1 using magnetic immunoassay technique on Magneto-Nanosensor platform. The high sensitivity of our detection platform combined with the early antibody biomarker can serve as a powerful diagnostic tool for enabling early detection of ovarian cancer.
UR - http://www.scopus.com/inward/record.url?scp=84942446756&partnerID=8YFLogxK
U2 - 10.1109/INTMAG.2015.7157494
DO - 10.1109/INTMAG.2015.7157494
M3 - Conference contribution
AN - SCOPUS:84942446756
T3 - 2015 IEEE International Magnetics Conference, INTERMAG 2015
BT - 2015 IEEE International Magnetics Conference, INTERMAG 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2015 IEEE International Magnetics Conference, INTERMAG 2015
Y2 - 11 May 2015 through 15 May 2015
ER -