Magnetic resonance spectroscopy as a tool for psychopharmacological studies

In Kyoon Lyoo, Perry F. Renshaw

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Lithium has a natural abundance of 93% and a relatively high MR visibility, 29% relative to hydrogen CH). As therapeutic serum levels are in the range of 1 mEqlL, brain lithium levels may be detected and quantified with relative ease [1]. This was first demonstrated by Renshaw and Wicklund reference lithium brain lithium 50 40 30 20 10 ppm o −10 −20 FIGURE 1 7Li-MRS. Lithium resonances from a 6-cm axial slice through the brain (center) and from an external standard (left). (Data from the McLean Hospital Brain Imaging Center.) in 1988 [2] (Fig. 1); subsequently, a number of research groups have developed methods for measuring brain lithium levels [3,4]. In practice the major problems associated with measuring brain lithium levels are the hardware requirements for detection of the lithium-7 eLi) nucleus and the relatively slow relaxation rates of this weakly quadrupolar, spin 3/2 nucleus [5].

Original languageEnglish
Title of host publicationBrain Imaging in Affective Disorders
PublisherCRC Press
Number of pages38
ISBN (Electronic)9781420028881
ISBN (Print)9780824708849
StatePublished - 1 Jan 2002

Bibliographical note

Publisher Copyright:
© 2002 by Taylor & Francis Group, LLC.


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