Magnetic Nanoparticle-Embedded Hydrogel Sheet with a Groove Pattern for Wound Healing Application

Miyeon Noh, Young Hwan Choi, Young Hyeon An, Dongha Tahk, Sungwoo Cho, Jung Won Yoon, Noo Li Jeon, Tai Hyun Park, Jaeho Kim, Nathaniel S. Hwang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Endothelial progenitor cells (EPCs) can induce a pro-angiogenic response during tissue repair. Recently, EPC transplantations have been widely investigated in wound healing applications. To maximize the healing efficacy by EPCs, a unique scaffold design that allows cell retention and function would be desirable for in situ delivery. Herein, we fabricated an alginate/poly-l-ornithine/gelatin (alginate-PLO-gelatin) hydrogel sheet with a groove pattern for use as a cell delivery platform. In addition, we demonstrate the topographical modification of the hydrogel sheet surface with a groove pattern to modulate cell proliferation, alignment, and elongation. We report that the patterned substrate prompted morphological changes of endothelial cells, increased cell-cell interaction, and resulted in the active secretion of growth factors such as PDGF-BB. Additionally, we incorporated magnetic nanoparticles (MNPs) into the patterned hydrogel sheet for the magnetic field-induced transfer of cell-seeded hydrogel sheets. As a result, enhanced wound healing was observed via efficient transplantation of the EPCs with an MNP-embedded patterned hydrogel sheet (MPS). Finally, enhanced vascularization and dermal wound repair were observed with EPC seeded MPS.

Original languageEnglish
Pages (from-to)3909-3921
Number of pages13
JournalACS Biomaterials Science and Engineering
Volume5
Issue number8
DOIs
StatePublished - 12 Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

  • angiogenesis
  • groove pattern
  • hydrogel
  • magnetic nanoparticles
  • vascularization
  • wound healing

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