Macroscopic highly aligned DNA nanowires created by controlled evaporative self-assembly

Bo Li, Wei Han, Myunghwan Byun, Lei Zhu, Qingze Zou, Zhiqun Lin

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


By subjecting DNA aqueous solution to evaporate in a curve-on-flat geometry that was composed of either a spherical lens or a cylindrical lens situated on a flat substrate, a set of highly aligned DNA nanowires in the forms of spokes and parallel stripes over a macroscopic area (i.e., millimeter scale) were successfully created. The DNA molecules were stretched and aligned on polymer-coated substrate by the receding meniscus. The imposed curve-on-flat geometry provided a unique environment for controlling the flow within the evaporating solution by eliminating temperature gradient and possible convective instability and, thus, regulated the formation of DNA nanowires. Such controlled evaporative self-assembly is remarkably easy to implement and opens up a new avenue for crafting large-scale DNA-based nanostructures in a simple and cost-effective manner, dispensing with the need for lithography techniques.

Original languageEnglish
Pages (from-to)4326-4333
Number of pages8
JournalACS Nano
Issue number5
StatePublished - 28 May 2013


  • DNA nanowire
  • confined geometry
  • controlled evaporation self-assembly


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