Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

E. K. Seo; N. C. Kim; Q. Mi; H. Chai; M. E. Wall; M. C. Wani; H. A. Navarro; J. P. Burgess; J. G. Graham; F. Cabieses; G. T. Tan; N. R. Farnsworth; J. M. Pezzuto; A. D. Kinghorn

doi:10.1021/np0103158

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

E. K. Seo
, N. C. Kim
, Q. Mi
, H. Chai
, M. E. Wall
, M. C. Wani
, H. A. Navarro
, J. P. Burgess
, J. G. Graham
, F. Cabieses
, G. T. Tan
, N. R. Farnsworth
, J. M. Pezzuto
, A. D. Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

Original language	English
Pages (from-to)	1483-1485
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	11
DOIs	https://doi.org/10.1021/np0103158
State	Published - 2001

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@article{05171dab3ddb4905916a537af1b2b08e,

title = "Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum",

abstract = "A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.",

author = "Seo, \{E. K.\} and Kim, \{N. C.\} and Q. Mi and H. Chai and Wall, \{M. E.\} and Wani, \{M. C.\} and Navarro, \{H. A.\} and Burgess, \{J. P.\} and Graham, \{J. G.\} and F. Cabieses and Tan, \{G. T.\} and Farnsworth, \{N. R.\} and Pezzuto, \{J. M.\} and Kinghorn, \{A. D.\}",

year = "2001",

doi = "10.1021/np0103158",

language = "English",

volume = "64",

pages = "1483--1485",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

AU - Seo, E. K.

AU - Kim, N. C.

AU - Mi, Q.

AU - Chai, H.

AU - Wall, M. E.

AU - Wani, M. C.

AU - Navarro, H. A.

AU - Burgess, J. P.

AU - Graham, J. G.

AU - Cabieses, F.

AU - Tan, G. T.

AU - Farnsworth, N. R.

AU - Pezzuto, J. M.

AU - Kinghorn, A. D.

PY - 2001

Y1 - 2001

N2 - A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

AB - A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

UR - https://www.scopus.com/pages/publications/0035199743

U2 - 10.1021/np0103158

DO - 10.1021/np0103158

M3 - Article

C2 - 11720542

AN - SCOPUS:0035199743

SN - 0163-3864

VL - 64

SP - 1483

EP - 1485

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

Abstract

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