Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

E. K. Seo; N. C. Kim; Q. Mi; H. Chai; M. E. Wall; M. C. Wani; H. A. Navarro; J. P. Burgess; J. G. Graham; F. Cabieses; G. T. Tan; N. R. Farnsworth; J. M. Pezzuto; A. D. Kinghorn

doi:10.1021/np0103158

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

E. K. Seo, N. C. Kim, Q. Mi, H. Chai, M. E. Wall, M. C. Wani, H. A. Navarro, J. P. Burgess, J. G. Graham, F. Cabieses, G. T. Tan, N. R. Farnsworth, J. M. Pezzuto, A. D. Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

Original language	English
Pages (from-to)	1483-1485
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	11
DOIs	https://doi.org/10.1021/np0103158
State	Published - 2001

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title = "Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum",

abstract = "A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.",

author = "Seo, {E. K.} and Kim, {N. C.} and Q. Mi and H. Chai and Wall, {M. E.} and Wani, {M. C.} and Navarro, {H. A.} and Burgess, {J. P.} and Graham, {J. G.} and F. Cabieses and Tan, {G. T.} and Farnsworth, {N. R.} and Pezzuto, {J. M.} and Kinghorn, {A. D.}",

year = "2001",

doi = "10.1021/np0103158",

language = "English",

volume = "64",

pages = "1483--1485",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "11",

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TY - JOUR

T1 - Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

AU - Seo, E. K.

AU - Kim, N. C.

AU - Mi, Q.

AU - Chai, H.

AU - Wall, M. E.

AU - Wani, M. C.

AU - Navarro, H. A.

AU - Burgess, J. P.

AU - Graham, J. G.

AU - Cabieses, F.

AU - Tan, G. T.

AU - Farnsworth, N. R.

AU - Pezzuto, J. M.

AU - Kinghorn, A. D.

PY - 2001

Y1 - 2001

N2 - A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

AB - A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

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U2 - 10.1021/np0103158

DO - 10.1021/np0103158

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C2 - 11720542

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SN - 0163-3864

VL - 64

SP - 1483

EP - 1485

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

Abstract

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