Lowering prostate-specific antigen threshold for prostate biopsy in Korean men: Impact on the number needing biopsy

Jin Seon Cho, Sun Il Kim, Se Joong Kim, Young Sig Kim, Chun Il Kim, Hong Sup Kim, Do Hwan Seong, Yun Seob Song, Dong Hyeon Lee, Won Jae Yang, Sang Hyeon Cheon, Kang Su Cho, In Rae Cho, Byung Ha Chung, Young Deuk Choi, Hyoungjune Im, Sung Joon Hong

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: We examined the effect of lowering prostate-specific antigen (PSA) threshold on the number of Korean men requiring a prostate biopsy. Materials and methods: We evaluated men who had serum PSA levels tested at routine physical check-ups between 1999 and 2005 at 11 domestic hospitals. Men with PSA ≥ 10ng/ml or patients with prostate cancer were excluded. A total of 45,074 men (aged 50 to 79 years) were enrolled and split into three age groups: 50-59 years, 60-69 years, and 70-79 years. For each age group, we calculated the number and proportion of men whose PSA level exceeded potential biopsy thresholds: 2.5ng/ml, 3.0ng/ml, and 4.0ng/ml. Results were extrapolated to the 4.992 million men older than 50 years old, or 21.3% of the Korean male population in 2005. Results: The number of biopsy candidates at the threshold of 4.0ng/ ml, 3.0ng/ml, and 2.5ng/ml were 1,321 (2.9%), 2,248 (5.4%), and 3,577 (7.9%), respectively. Extrapolating to the male population in Korea, lowering the PSA threshold from 4.0ng/ml to 3.0 or 2.5ng/ml would increase the number of men needing biopsy by 1.75 and 2.49 times, respectively. Conclusions: Lowering the PSA threshold would increase the number of men receiving prostate biopsy despite the low reference age for PSA in Korea. Considering the low incidence of prostate cancer, physicians should be careful in altering the PSA threshold.

Original languageEnglish
Pages (from-to)118-121
Number of pages4
JournalKorean Journal of Urology
Issue number2
StatePublished - Feb 2008


  • Biopsy
  • Prostate-specific antigen
  • Threshold


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