Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I-FP-CIT SPECT

Yun Jung Bae; Jong Min Kim; Eunhee Kim; Kyung Mi Lee; Seo Young Kang; Hyun Soo Park; Kyeong Joon Kim; Young Eun Kim; Eung Seok Oh; Ji Young Yun; Ji Seon Kim; Hye Jin Jeong; Beomseok Jeon; Sang Eun Kim

doi:10.1002/mds.26584

Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With ¹²³I-FP-CIT SPECT

Yun Jung Bae, Jong Min Kim, Eunhee Kim, Kyung Mi Lee, Seo Young Kang, Hyun Soo Park, Kyeong Joon Kim, Young Eun Kim, Eung Seok Oh, Ji Young Yun, Ji Seon Kim, Hye Jin Jeong, Beomseok Jeon, Sang Eun Kim

Department of Neurology

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Background: The aim of this study was to investigate whether 3 Tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by ¹²³I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. Methods: Consecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow-up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility-weighted imaging. The performance of susceptibility-weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results. Results: The study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false-negative cases and 11 false-positive cases. The sensitivity and specificity of susceptibility-weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility-weighted imaging and single photon emission computerized tomography was 86.2%. Conclusions: The loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by ¹²³I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging.

Original language	English
Pages (from-to)	684-692
Number of pages	9
Journal	Movement Disorders
Volume	31
Issue number	5
DOIs	https://doi.org/10.1002/mds.26584
State	Published - 1 May 2016

Bibliographical note

Funding Information:
The Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health & Welfare, Korea (HI09C1444, HI14C1072), and the National Research Foundation of Korea grant, the Ministry of Science, ICT, and Future Planning, Korea (NRF-2014M3C7A1046042). For Beomseok Jeon, travel grants from Korea Research-Based Pharmaceutical Industry Association, Korean Pharmaceutical Manufacturers Association, Seoul National University, Seoul National University Hospital; research grants from the Ministry of Health and Welfare, Seoul National University Hospital, Sinyang Cultural Foundation, Song Foundation, Korean Movement Disorder Society, Samil Pharmaceuticals, Abbvie Korea, UCB Korea, Ipsen Korea, Sandoz Korea, Lundbeck Korea, Novartis Korea; consultantfor Lundbeck Korea; speaker's bureau honoraria from Ipsen, UCB. Forothers, there is nothing to report.

Publisher Copyright:
© 2016 International Parkinson and Movement Disorder Society.

Keywords

Magnetic resonance imaging
Multiple system atrophy
Parkinson's disease
Progressive supranuclear palsy

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10.1002/mds.26584

Cite this

@article{d58da610d959424e83ecf4de5bdd04e6,

title = "Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I-FP-CIT SPECT",

abstract = "Background: The aim of this study was to investigate whether 3 Tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. Methods: Consecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow-up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility-weighted imaging. The performance of susceptibility-weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results. Results: The study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false-negative cases and 11 false-positive cases. The sensitivity and specificity of susceptibility-weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility-weighted imaging and single photon emission computerized tomography was 86.2%. Conclusions: The loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging.",

keywords = "Magnetic resonance imaging, Multiple system atrophy, Parkinson's disease, Progressive supranuclear palsy",

author = "Bae, {Yun Jung} and Kim, {Jong Min} and Eunhee Kim and Lee, {Kyung Mi} and Kang, {Seo Young} and Park, {Hyun Soo} and Kim, {Kyeong Joon} and Kim, {Young Eun} and Oh, {Eung Seok} and Yun, {Ji Young} and Kim, {Ji Seon} and Jeong, {Hye Jin} and Beomseok Jeon and Kim, {Sang Eun}",

note = "Funding Information: The Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health & Welfare, Korea (HI09C1444, HI14C1072), and the National Research Foundation of Korea grant, the Ministry of Science, ICT, and Future Planning, Korea (NRF-2014M3C7A1046042). For Beomseok Jeon, travel grants from Korea Research-Based Pharmaceutical Industry Association, Korean Pharmaceutical Manufacturers Association, Seoul National University, Seoul National University Hospital; research grants from the Ministry of Health and Welfare, Seoul National University Hospital, Sinyang Cultural Foundation, Song Foundation, Korean Movement Disorder Society, Samil Pharmaceuticals, Abbvie Korea, UCB Korea, Ipsen Korea, Sandoz Korea, Lundbeck Korea, Novartis Korea; consultantfor Lundbeck Korea; speaker's bureau honoraria from Ipsen, UCB. Forothers, there is nothing to report. Publisher Copyright: {\textcopyright} 2016 International Parkinson and Movement Disorder Society.",

year = "2016",

month = may,

day = "1",

doi = "10.1002/mds.26584",

language = "English",

volume = "31",

pages = "684--692",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism

T2 - Comparison With 123I-FP-CIT SPECT

AU - Bae, Yun Jung

AU - Kim, Jong Min

AU - Kim, Eunhee

AU - Lee, Kyung Mi

AU - Kang, Seo Young

AU - Park, Hyun Soo

AU - Kim, Kyeong Joon

AU - Kim, Young Eun

AU - Oh, Eung Seok

AU - Yun, Ji Young

AU - Kim, Ji Seon

AU - Jeong, Hye Jin

AU - Jeon, Beomseok

AU - Kim, Sang Eun

N1 - Funding Information: The Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health & Welfare, Korea (HI09C1444, HI14C1072), and the National Research Foundation of Korea grant, the Ministry of Science, ICT, and Future Planning, Korea (NRF-2014M3C7A1046042). For Beomseok Jeon, travel grants from Korea Research-Based Pharmaceutical Industry Association, Korean Pharmaceutical Manufacturers Association, Seoul National University, Seoul National University Hospital; research grants from the Ministry of Health and Welfare, Seoul National University Hospital, Sinyang Cultural Foundation, Song Foundation, Korean Movement Disorder Society, Samil Pharmaceuticals, Abbvie Korea, UCB Korea, Ipsen Korea, Sandoz Korea, Lundbeck Korea, Novartis Korea; consultantfor Lundbeck Korea; speaker's bureau honoraria from Ipsen, UCB. Forothers, there is nothing to report. Publisher Copyright: © 2016 International Parkinson and Movement Disorder Society.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: The aim of this study was to investigate whether 3 Tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. Methods: Consecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow-up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility-weighted imaging. The performance of susceptibility-weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results. Results: The study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false-negative cases and 11 false-positive cases. The sensitivity and specificity of susceptibility-weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility-weighted imaging and single photon emission computerized tomography was 86.2%. Conclusions: The loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging.

AB - Background: The aim of this study was to investigate whether 3 Tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. Methods: Consecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow-up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility-weighted imaging. The performance of susceptibility-weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results. Results: The study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false-negative cases and 11 false-positive cases. The sensitivity and specificity of susceptibility-weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility-weighted imaging and single photon emission computerized tomography was 86.2%. Conclusions: The loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging.

KW - Magnetic resonance imaging

KW - Multiple system atrophy

KW - Parkinson's disease

KW - Progressive supranuclear palsy

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U2 - 10.1002/mds.26584

DO - 10.1002/mds.26584

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JO - Movement Disorders

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