TY - JOUR
T1 - Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease
AU - Lee, Jae Seung
AU - Kim, Seon Ok
AU - Seo, Joon Beom
AU - Lee, Ji Hyun
AU - Kim, Eun Kyung
AU - Kim, Tae Hyung
AU - Kim, Woo Jin
AU - Lee, Jin Hwa
AU - Lee, Sang Min
AU - Lee, Sangyeub
AU - Lim, Seong Yong
AU - Shin, Tae Rim
AU - Yoon, Ho Il
AU - Lee, Sei Won
AU - Huh, Jin Won
AU - Oh, Yeon Mok
AU - Lee, Sang Do
N1 - Funding Information:
This study was supported by Grants from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare Affairs, Republic of Korea (A102065).
PY - 2013/8
Y1 - 2013/8
N2 - Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.
AB - Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.
KW - Chronic obstructive pulmonary disease
KW - Inspiratory capacity
KW - Lung volume measurements
KW - Spirometry
KW - Total lung capacity
UR - http://www.scopus.com/inward/record.url?scp=84880828247&partnerID=8YFLogxK
U2 - 10.1007/s00408-013-9478-0
DO - 10.1007/s00408-013-9478-0
M3 - Article
C2 - 23715996
AN - SCOPUS:84880828247
SN - 0341-2040
VL - 191
SP - 405
EP - 412
JO - Lung
JF - Lung
IS - 4
ER -