Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease

Jae Seung Lee, Seon Ok Kim, Joon Beom Seo, Ji Hyun Lee, Eun Kyung Kim, Tae Hyung Kim, Woo Jin Kim, Jin Hwa Lee, Sang Min Lee, Sangyeub Lee, Seong Yong Lim, Tae Rim Shin, Ho Il Yoon, Sei Won Lee, Jin Won Huh, Yeon Mok Oh, Sang Do Lee

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.

Original languageEnglish
Pages (from-to)405-412
Number of pages8
Issue number4
StatePublished - Aug 2013

Bibliographical note

Funding Information:
This study was supported by Grants from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare Affairs, Republic of Korea (A102065).


  • Chronic obstructive pulmonary disease
  • Inspiratory capacity
  • Lung volume measurements
  • Spirometry
  • Total lung capacity


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