Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease

Hanna Cho; Seun Jeon; Sue J. Kang; Jong Min Lee; Jae Hong Lee; Geon Ha Kim; Ji Soo Shin; Chi Hun Kim; Young Noh; Kiho Im; Sung Tae Kim; Juhee Chin; Sang Won Seo; Duk L. Na

doi:10.1016/j.neurobiolaging.2013.01.004

Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease

Hanna Cho, Seun Jeon, Sue J. Kang, Jong Min Lee, Jae Hong Lee, Geon Ha Kim, Ji Soo Shin, Chi Hun Kim, Young Noh, Kiho Im, Sung Tae Kim, Juhee Chin, Sang Won Seo, Duk L. Na

Department of Neurology

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests.

Original language	English
Pages (from-to)	1921.e9-1921.e15
Journal	Neurobiology of Aging
Volume	34
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.01.004
State	Published - Jul 2013

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (No. A102065 , A110719 , and A070001 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government ( MEST; 2011-0028333 ), a Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ).

Keywords

Alzheimer's disease
Cortical thickness
Early onset
Longitudinal study
Onset age

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10.1016/j.neurobiolaging.2013.01.004

Cite this

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title = "Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease",

abstract = "Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests.",

keywords = "Alzheimer's disease, Cortical thickness, Early onset, Longitudinal study, Onset age",

author = "Hanna Cho and Seun Jeon and Kang, {Sue J.} and Lee, {Jong Min} and Lee, {Jae Hong} and Kim, {Geon Ha} and Shin, {Ji Soo} and Kim, {Chi Hun} and Young Noh and Kiho Im and Kim, {Sung Tae} and Juhee Chin and Seo, {Sang Won} and Na, {Duk L.}",

note = "Funding Information: This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (No. A102065 , A110719 , and A070001 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government ( MEST; 2011-0028333 ), a Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ). ",

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AU - Cho, Hanna

AU - Jeon, Seun

AU - Kang, Sue J.

AU - Lee, Jong Min

AU - Lee, Jae Hong

AU - Kim, Geon Ha

AU - Shin, Ji Soo

AU - Kim, Chi Hun

AU - Noh, Young

AU - Im, Kiho

AU - Kim, Sung Tae

AU - Chin, Juhee

AU - Seo, Sang Won

AU - Na, Duk L.

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PY - 2013/7

Y1 - 2013/7

N2 - Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests.

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KW - Onset age

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ER -

Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease

Abstract

Bibliographical note

Keywords

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