Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease

Hanna Cho, Seun Jeon, Sue J. Kang, Jong Min Lee, Jae Hong Lee, Geon Ha Kim, Ji Soo Shin, Chi Hun Kim, Young Noh, Kiho Im, Sung Tae Kim, Juhee Chin, Sang Won Seo, Duk L. Na

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86 Scopus citations


Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests.

Original languageEnglish
Pages (from-to)1921.e9-1921.e15
JournalNeurobiology of Aging
Issue number7
StatePublished - Jul 2013

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (No. A102065 , A110719 , and A070001 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government ( MEST; 2011-0028333 ), a Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ).


  • Alzheimer's disease
  • Cortical thickness
  • Early onset
  • Longitudinal study
  • Onset age


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