Long-term results of forward intensity-modulated radiation therapy for patients with early-stage breast cancer

Boram Ha, Hyun Suk Suh, Jihae Lee, Kyung Ja Lee, Rena Lee, Byung In Moon

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Purpose: To observe long-term clinical outcomes for patients with early-stage breast cancer treated with forward intensity-modulated radiation therapy (IMRT), including local control and clinical toxicities. Materials and Methods: We retrospectively analyzed a total of 214 patients with stage I-II breast cancer who were treated with breast conserving surgery followed by adjuvant breast radiation therapy between 2001 and 2008. All patients were treated using forward IMRT. The whole breast was irradiated to a dose of 50 to 50.4 Gy followed by an 8 to 12 Gy electron boost to the surgical bed. Results: The median age was 46 years (range, 21 to 82 years) and the medial follow-up time was 7.3 years (range, 2.4 to 11.7 years). Stage T1 was 139 (65%) and T2 was 75 (35%), respectively. Ipsilateral breast recurrence was observed in 3 patients. The 5- and 10-year local control rates were 99.1% and 97.8%, respectively. The cosmetic outcome was evaluated according to the Harvard scale and 89.4% of patients were scored as excellent or good. Conclusion: The whole breast radiation therapy as an adjuvant treatment using a forward IMRT technique showed excellent long-term local control as well as favorable outcomes of toxicity and cosmesis.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalRadiation Oncology Journal
Volume31
Issue number4
DOIs
StatePublished - Dec 2013

Keywords

  • Breast neoplasms
  • Forward intensity modulated radiation therapy
  • Local control

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