Long-term recurrence rates of peptic ulcers without Helicobacter pylori

Jae Hyun Seo, Su Jin Hong, Jie Hyun Kim, Byung Wook Kim, Sam Ryong Jee, Woo Chul Chung, Ki Nam Shim, Gwang Ho Baik, Sung Soo Kim, Sang Gyun Kim, Jin Il Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, Male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, Male, and comorbid chronic kidney disease.

Original languageEnglish
Pages (from-to)719-725
Number of pages7
JournalGut and Liver
Issue number5
StatePublished - Sep 2016


  • Helicobacter negative
  • Natural course
  • Peptic ulcer disease


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