Abstract
Background: Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficient. This study aimed to investigate the long-term outcomes of ECC removal by ESD, including local recurrence and metastasis. Methods: This multicenter study was conducted retrospectively on 450 consecutive patients with ECC who were treated with ESD between November 2003 and December 2013. Clinical, pathological, and endoscopic data were collected to determine tumor depth, resection margin, lymphovascular invasion, and recurrence. Results: The median follow-up period was 53.8 (12–138 months). The en bloc resection rate was 85.3% (384) and in intramucosal cancer being 84.1% and in superficial submucosal invasion (SM1) cancer being 89.8% (p = 0.158). The curative resection rate was 76.0% (n = 342), and there was no statistical difference between the two groups (77.3% vs. 71.4%, p = 0.231). The overall recurrence free survival rate (RFS) was 98.7% (444/450). In patients with curative resection, there was no statistically significant difference in RFS according to invasion depth (intramucosal: 99.3% vs. SM1: 97.1%, p = 0.248). Conclusions: Patients with curatively resected ECC treated with ESD showed favorable long-term outcomes. Curatively resected SM1 cancer has a RFS similar to that of intramucosal cancer.
| Original language | English |
|---|---|
| Article number | 417 |
| Journal | BMC Gastroenterology |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 2022 |
Bibliographical note
Funding Information:None. Members of Korean Society of Gastrointestinal Endoscopy Su Jin Hong, M.D. Ph.D., Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon. Jung-Won Jeon, M.D. Ph.D., Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. Bong Min Ko, M.D., Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon. Weon Jin Ko, M.D., Division of Gastroenterology, Department of Internal Medicine, Inha University School of Medicine. Sun Moon Kim. M.D. Ph.D., Division of Gastroenterology Department of Internal Medicine, College of Medicine, Konyang University. Young Dae Kim, M.D. Ph.D., Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea. Eun Ran Kim, M.D. Ph.D., Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine. Kim Chan Gyoo, M.D. Ph.D., From the Center for Gastric Cancer and the Biometrics Research Branch, Research Institute, National Cancer Center, Goyang, South Korea. Gwang Ho Baik, M.D. Ph.D., Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. Dong Hoon Baek, M.D., Ph.D., Division of Gastoenterology, Department of Internal medicine, Pusan National University School of Medicine & Pusan National University Hospital. In Kyung Yoo, M.D., Ph.D., Department of Gastroenterology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam. Lee Kang Nyeong, M.D. Ph.D., Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. Si Hyung Lee, M.D., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine. Chul-Hyun Lim, M.D. Ph.D., Division of Gastroenterology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Hyun Joo Jang, M.D., Division of Gastroenterology and Hepatology, Department of Medicine, Dongtan Sacred Heart Hospital, Hallym University School of Medicine. Seong Woo Jeon, M.D., Internal Medicine, Kyungpook National University School of Medicine.
Publisher Copyright:
© 2022, The Author(s).
Keywords
- Early colorectal cancer
- Endoscopic submucosal dissection
- Recurrence free survival
