Long-term prognosis of combined hepatocellular and cholangiocarcinoma after curative resection comparison with hepatocellular carcinoma and cholangiocarcinoma

Jeong Hoon Lee, Goh Eun Chung, Su Jong Yu, Sang Youn Hwang, Joon Suk Kim, Hwi Young Kim, Jung Hwan Yoon, Hyo Suk Lee, Nam Joon Yi, Kyung Suk Suh, Kuhn Uk Lee, Ja June Jang, Yoon Jun Kim

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98 Scopus citations

Abstract

GOAL: In this study, we attempted to evaluate the prognosis of combined hepatocellular and cholangiocarcinoma (cHCC-CC) with comparison to hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CC). BACKGROUND: The prognosis of cHCC-CC has not been fully elucidated. In this study, we attempted to evaluate the prognosis of cHCC-CC with comparison to HCC and CC. STUDY: Consecutive patients who underwent curative resection for cHCC-CC at a single tertiary care center in Korea and their age, sex, and Child-Turcotte-Pugh class matched HCC and CC patients were included. We evaluated time-to-recurrence (TTR) and overall survival (OS) of cHCC-CC cases and compared them with HCC and CC patients. RESULTS: Thirty cHCC-CC, 60 HCC, and 60 CC patients were included. For cHCC-CC group, the median TTR and OS were 5.4 and 18.0 months. After adjustment for confounding factors, the cHCC-CC group had a shorter TTR than did HCC group [relative risk (RR), 2.76; P<0.001] and CC group (RR, 2.00; P=0.013), and a shorter OS than HCC group (RR, 4.70; P<0.001). Compared with the each stage I diseases, cHCC-CC had shorter TTR than HCC (RR, 4.59; P=0.001) and CC (RR, 2.74, P=0.015) and shorter OS than HCC (RR, 9.35; P=0.001). CONCLUSIONS: The results of this study indicated that cHCC-CC had a significantly poorer prognosis than HCC and CC even after curative resection.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume45
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • cholangiocarcinoma
  • combined hepatocellular and cholangiocarcinoma
  • curative resection
  • hepatocellular carcinoma
  • prognosis

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