Long-term patient-reported outcomes following laparoscopic cholecystectomy: A prospective multicenter observational study

In Woong Han, Hyeon Kook Lee, Dae Joon Park, Yoo Shin Choi, Seung Eun Lee, Hongbeom Kim, Wooil Kwon, Jin Young Jang, Huisong Lee, Jin Seok Heo, Somchai Amornyotin

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AbstractSeveral studies have reported short-term results for post-cholecystectomy symptoms and quality of life (QoL). However, reports on long-term results are still limited. This study aimed to identify risk factors affecting short- and long-term patient-reported outcome (PRO) following laparoscopic cholecystectomy.From 2016 to 2017, a total of 476 patients from 5 institutions were enrolled. PRO was examined using the Numeric Rating Scale (NRS) pain score and the Gastrointestinal (GI) QoL Index questionnaire at postoperative 1 month and 1 year.Most of patients recovered well at postoperative 1 year compared to postoperative 1 month for the NRS pain score, QoL score, and GI symptoms. A high operative difficulty score (HR 1.740, P =.031) and pathology of acute or complicated cholecystitis (HR 1.524, P =.048) were identified as independent risk factors for high NRS pain scores at postoperative 1 month. Similarly, female sex (HR 1.571, P = .003) at postoperative 1 month and postoperative complications (HR 5.567, P = .001) at postoperative 1 year were independent risk factors for a low QoL. Also, age above 50 (HR 1.842, P = .001), female sex (HR 1.531, P = .006), and preoperative gallbladder drainage (HR 3.086, P = .001) were identified as independent risk factors for GI symptoms at postoperative 1 month.Most patients showed improved long-term PRO measurement in terms of pain, QoL, and GI symptoms. There were no independent risk factors for long-term postoperative pain and GI symptoms. However, postoperative complications were identified to affect QoL adversely at postoperative 1 year. Careful and long-term follow up is thus necessary for patients who experienced postoperative complications.

Original languageEnglish
Article numbere21683
JournalMedicine (United States)
Issue number35
StatePublished - 28 Aug 2020

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  • laparoscopic cholecystectomy
  • patient-reported outcome
  • quality of life


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