Long-term outcome of laparoscopic versus open liver resection for hepatocellular carcinoma: A case-controlled study with propensity score matching

Hyeyoung Kim, Kyung Suk Suh, Kwang Woong Lee, Nam Joon Yi, Geun Hong, Suk Won Suh, Tae Yoo, Min Su Park, Youngrok Choi, Hae Won Lee

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Background: Laparoscopic liver resection (LR) for hepatocellular carcinoma (HCC) is usually applied to superficial and left-side small lesions. Therefore, well designed comparative studies about the results of LR versus open liver resection (OR) for HCC are difficult and still uncommon. The aim of this study was to compare the perioperative and long-term oncologic outcomes of LR versus OR for HCC between well-matched patient groups. Methods: Between January 2000 and March 2012, 205 patients (43 with intent-to-treat with LR, 162 OR) underwent primary liver resection of less than three segments for HCC in our center. To select a comparison group, propensity score matching (PSM) was used at 1:1 ratio with covariates of baseline characteristics, including tumor characteristics. Outcomes were compared between the matched groups. Results: The two groups were well balanced by PSM and 29 patients were matched respectively. In LR, there was more non-anatomical resection (65.5 vs. 34.5 %; p = 0.012), less postoperative ascites (0.0 vs. 17.2 %; p = 0.025), and shorter hospital stay (7.69 ± 2.94 vs. 13.38 ± 7.37 days; p < 0.001). With the exception of these, there were no significant differences in perioperative and long-term outcomes. The 1-, 3- and 5-year survivals were 100, 100 and 92.2 % in LR, and 96.5, 92.2 and 87.7 % in OR (p = 0.267), respectively. The 1-, 3- and 5-year disease-free survivals were 81.7, 61.7 and 54.0 % in LR, and 78.6, 60.9 and 40.1 % in OR, respectively (p = 0.929). Conclusions: The outcome of LR for HCC was technically feasible and safe in selected patients, and LR showed similar perioperative and long-term oncologic outcomes when compared with OR matched with PSM.

Original languageEnglish
Pages (from-to)950-960
Number of pages11
JournalSurgical Endoscopy
Volume28
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Case-controlled study
  • Hepatectomy
  • Hepatocellular carcinoma
  • Laparoscopic liver resection
  • Laparoscopy
  • Propensity score matching

Fingerprint

Dive into the research topics of 'Long-term outcome of laparoscopic versus open liver resection for hepatocellular carcinoma: A case-controlled study with propensity score matching'. Together they form a unique fingerprint.

Cite this