Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children

Hye Ah Lee, Bo Hyun Park, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hyesook Park

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. Methods: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes. Results: Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (β = - 0.07, p < 0.05), but there were no significant differences by sex. The effects of rs3825017 on UA concentration were significant in boys, but not in girls. Boys with the T allele of rs3825017 had higher concentrations than their counterparts regardless of the time of follow-up. The rs16890979 genotypes were not significantly associated with serum UA concentration in either sex. Conclusion: This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood.

Original languageEnglish
Article number296
JournalBMC Pediatrics
Volume18
Issue number1
DOIs
StatePublished - 6 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Keywords

  • Children
  • Longitudinal study
  • Urate transporter 1
  • Uric acid

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