@inproceedings{b79af2dfef6a4dd5b7a59e4d9dbd1fb3,
title = "Long-term cytotoxic drug assay via single-cell microfluidic array",
abstract = "In this work, we use a single cell trapping array device for cytotoxic drug investigations on a large amount of single cells. The uniform and precise microenvironment for each single cell rigorously controls the drug assay experiment. The dynamic perfusion flow supplies media with/without drug to properly simulate the in vivo drug delivery mode. Drug assays for both adherent and non-adherent cell lines were demonstrated in the device. We have evaluated dose conditions of Taxol on HeLa and HL-60 cells. By tracing each single cells before, during and after the drug exposure, we first correlate the lifetime of the cells and their condition when exposing to the drug.",
keywords = "Cell culture, Drug assay, Microfluidic devices, Single cell analysis",
author = "Wu, {Liz Y.} and {Di Carlo}, Dino and Lee, {Luke P.}",
note = "Funding Information: This research was supported by Intel Research Fund, GSK, Taiwan Merit Scholarship TMS-094-2-A-008 (L.W.) Funding Information: This research was supported by Intel eR search Fund, GSK, Taiwan Merit Scholarship TMS-094-2-A-008 (L.W.) Publisher Copyright: {\textcopyright} 2007 CBMS.; 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 ; Conference date: 07-10-2007 Through 11-10-2007",
year = "2007",
language = "English",
series = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
publisher = "Chemical and Biological Microsystems Society",
pages = "709--711",
editor = "Jean-Louis Viovy and Patrick Tabeling and Stephanie Descroix and Laurent Malaquin",
booktitle = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
}