Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort

Hyunji Jo; Seri Park; Hye Ryeon Kim; Hongsik Kim; Joohyun Hong; Jeong Eon Lee; Jonghan Yu; Byung Joo Chae; Se Kyung Lee; Jai Min Ryu; Soo Young Oh; Suk Joo Choi; Ji Yeon Kim; Jin Seok Ahn; Young Hyuck Im; Eun Mi Nam; Seok Jin Nam; Yeon Hee Park

doi:10.3390/cancers14194839

Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort

Hyunji Jo, Seri Park, Hye Ryeon Kim, Hongsik Kim, Joohyun Hong, Jeong Eon Lee, Jonghan Yu, Byung Joo Chae, Se Kyung Lee, Jai Min Ryu, Soo Young Oh, Suk Joo Choi, Ji Yeon Kim, Jin Seok Ahn, Young Hyuck Im, Eun Mi Nam, Seok Jin Nam, Yeon Hee Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Given that peak age of breast cancer (BC) is younger in Asians than in Western populations, relatively higher prevalence of pregnancy-associated breast cancer (PABC) has been reported. This study aimed to analyze the characteristics and clinical outcomes of PABC in Korea. Methods: We defined PABC as BC diagnosed during pregnancy or in the first postpartum year. We compared the clinicopathological characteristics and BC outcomes between patients with PABC and non-PABC patients in the prospective YBC cohort from Samsung Medical Center. Results: In total, 1492 patients were initially enrolled, and 1364 patients were included, of which 93 had PABC (6.8%). The median age of patients with PABC was 34 years. Hormone receptor expression was lower (64.6% vs 74.6%) and frequency of HER2 overexpression was higher (26.9% vs 17.6%) in patients with PABC than in non-PABC patients. The 5-year overall survival (OS) rates were 83.2% and 93.4% in patients with PABC and non-PABC patients, respectively (p < 0.001). The 5-year disease-free survival (DFS) rates were 72.2% and 83.8% in PABC and non-PABC patients. Conclusion: Compared to non-PABC patients, patients with PABC had poorer OS and DFS in this prospective cohort. Exploratory biomarker analysis for PABC is warranted.

Original language	English
Article number	4839
Journal	Cancers
Volume	14
Issue number	19
DOIs	https://doi.org/10.3390/cancers14194839
State	Published - Oct 2022

Bibliographical note

Funding Information:
This study was supported by Future Medicine 2030 Project of the Samsung Medical Center [SMO1220031].

Publisher Copyright:
© 2022 by the authors.

Keywords

breast cancer
pregnancy
prospective cohort

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10.3390/cancers14194839

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Jo, H., Park, S., Kim, H. R., Kim, H., Hong, J., Lee, J. E., Yu, J., Chae, B. J., Lee, S. K., Ryu, J. M., Oh, S. Y., Choi, S. J., Kim, J. Y., Ahn, J. S., Im, Y. H., Nam, E. M., Nam, S. J., & Park, Y. H. (2022). Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort. Cancers, 14(19), Article 4839. https://doi.org/10.3390/cancers14194839

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title = "Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort",

abstract = "Background: Given that peak age of breast cancer (BC) is younger in Asians than in Western populations, relatively higher prevalence of pregnancy-associated breast cancer (PABC) has been reported. This study aimed to analyze the characteristics and clinical outcomes of PABC in Korea. Methods: We defined PABC as BC diagnosed during pregnancy or in the first postpartum year. We compared the clinicopathological characteristics and BC outcomes between patients with PABC and non-PABC patients in the prospective YBC cohort from Samsung Medical Center. Results: In total, 1492 patients were initially enrolled, and 1364 patients were included, of which 93 had PABC (6.8%). The median age of patients with PABC was 34 years. Hormone receptor expression was lower (64.6% vs 74.6%) and frequency of HER2 overexpression was higher (26.9% vs 17.6%) in patients with PABC than in non-PABC patients. The 5-year overall survival (OS) rates were 83.2% and 93.4% in patients with PABC and non-PABC patients, respectively (p < 0.001). The 5-year disease-free survival (DFS) rates were 72.2% and 83.8% in PABC and non-PABC patients. Conclusion: Compared to non-PABC patients, patients with PABC had poorer OS and DFS in this prospective cohort. Exploratory biomarker analysis for PABC is warranted.",

keywords = "breast cancer, pregnancy, prospective cohort",

author = "Hyunji Jo and Seri Park and Kim, {Hye Ryeon} and Hongsik Kim and Joohyun Hong and Lee, {Jeong Eon} and Jonghan Yu and Chae, {Byung Joo} and Lee, {Se Kyung} and Ryu, {Jai Min} and Oh, {Soo Young} and Choi, {Suk Joo} and Kim, {Ji Yeon} and Ahn, {Jin Seok} and Im, {Young Hyuck} and Nam, {Eun Mi} and Nam, {Seok Jin} and Park, {Yeon Hee}",

note = "Funding Information: This study was supported by Future Medicine 2030 Project of the Samsung Medical Center [SMO1220031]. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/cancers14194839",

language = "English",

volume = "14",

journal = "Cancers",

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T1 - Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort

AU - Jo, Hyunji

AU - Park, Seri

AU - Kim, Hye Ryeon

AU - Kim, Hongsik

AU - Hong, Joohyun

AU - Lee, Jeong Eon

AU - Yu, Jonghan

AU - Chae, Byung Joo

AU - Lee, Se Kyung

AU - Ryu, Jai Min

AU - Oh, Soo Young

AU - Choi, Suk Joo

AU - Kim, Ji Yeon

AU - Ahn, Jin Seok

AU - Im, Young Hyuck

AU - Nam, Eun Mi

AU - Nam, Seok Jin

AU - Park, Yeon Hee

PY - 2022/10

Y1 - 2022/10

N2 - Background: Given that peak age of breast cancer (BC) is younger in Asians than in Western populations, relatively higher prevalence of pregnancy-associated breast cancer (PABC) has been reported. This study aimed to analyze the characteristics and clinical outcomes of PABC in Korea. Methods: We defined PABC as BC diagnosed during pregnancy or in the first postpartum year. We compared the clinicopathological characteristics and BC outcomes between patients with PABC and non-PABC patients in the prospective YBC cohort from Samsung Medical Center. Results: In total, 1492 patients were initially enrolled, and 1364 patients were included, of which 93 had PABC (6.8%). The median age of patients with PABC was 34 years. Hormone receptor expression was lower (64.6% vs 74.6%) and frequency of HER2 overexpression was higher (26.9% vs 17.6%) in patients with PABC than in non-PABC patients. The 5-year overall survival (OS) rates were 83.2% and 93.4% in patients with PABC and non-PABC patients, respectively (p < 0.001). The 5-year disease-free survival (DFS) rates were 72.2% and 83.8% in PABC and non-PABC patients. Conclusion: Compared to non-PABC patients, patients with PABC had poorer OS and DFS in this prospective cohort. Exploratory biomarker analysis for PABC is warranted.

AB - Background: Given that peak age of breast cancer (BC) is younger in Asians than in Western populations, relatively higher prevalence of pregnancy-associated breast cancer (PABC) has been reported. This study aimed to analyze the characteristics and clinical outcomes of PABC in Korea. Methods: We defined PABC as BC diagnosed during pregnancy or in the first postpartum year. We compared the clinicopathological characteristics and BC outcomes between patients with PABC and non-PABC patients in the prospective YBC cohort from Samsung Medical Center. Results: In total, 1492 patients were initially enrolled, and 1364 patients were included, of which 93 had PABC (6.8%). The median age of patients with PABC was 34 years. Hormone receptor expression was lower (64.6% vs 74.6%) and frequency of HER2 overexpression was higher (26.9% vs 17.6%) in patients with PABC than in non-PABC patients. The 5-year overall survival (OS) rates were 83.2% and 93.4% in patients with PABC and non-PABC patients, respectively (p < 0.001). The 5-year disease-free survival (DFS) rates were 72.2% and 83.8% in PABC and non-PABC patients. Conclusion: Compared to non-PABC patients, patients with PABC had poorer OS and DFS in this prospective cohort. Exploratory biomarker analysis for PABC is warranted.

KW - breast cancer

KW - pregnancy

KW - prospective cohort

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U2 - 10.3390/cancers14194839

DO - 10.3390/cancers14194839

M3 - Article

AN - SCOPUS:85139844608

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 19

M1 - 4839

ER -

Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort

Abstract

Bibliographical note

Keywords

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