Abstract
Long non-coding RNAs (lncRNAs) regulate diverse physiological and pathological processes via post-transcriptional, post-translational, and epigenetic mechanisms. They are also involved in tumor initiation, progression, and metastasis by functioning as key players in the tumor microenvironment. Cancer-associated fibroblasts (CAFs) promote tumor initiation, progression, metastasis, drug resistance, and immunosuppression, which can be modulated by lncRNAs. LncRNAs regulate the intrinsic properties of CAFs or cancer cells intracellularly or function extracellularly through exosomal secretion. In-depth studies on the mechanisms of lncRNA functions will enable their clinical use as diagnosis/prognosis markers and therapeutic targets in cancer treatment.
| Original language | English |
|---|---|
| Article number | 7484 |
| Pages (from-to) | 1-16 |
| Number of pages | 16 |
| Journal | International Journal of Molecular Sciences |
| Volume | 21 |
| Issue number | 20 |
| DOIs | |
| State | Published - 2 Oct 2020 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) grants funded by the government of Korea (MSIT) (NRF-2019R1F1A1057968 and NRF-2020R1A5A2019210).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Cancer-associated fibroblasts
- Long non-coding RNAs
- Tumor microenvironment