Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le; Chae Yoon Yim; Songhee Park; Nikita Katila; Inho Yang; Myoung Chong Song; Yeo Joon Yoon; Dong Young Choi; Hyukjae Choi; Sang Jip Nam; William Fenical

doi:10.1016/j.bmcl.2017.05.035

Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le
, Chae Yoon Yim
, Songhee Park
, Nikita Katila
, Inho Yang
, Myoung Chong Song
, Yeo Joon Yoon
, Dong Young Choi
, Hyukjae Choi
, Sang Jip Nam
, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Original language	English
Pages (from-to)	3123-3126
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2017.05.035
State	Published - 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

BACE1 inhibitor
Lodopyridone
Marine natural products
Saccharomonospora

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10.1016/j.bmcl.2017.05.035

Cite this

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title = "Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.",

abstract = "HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).",

keywords = "BACE1 inhibitor, Lodopyridone, Marine natural products, Saccharomonospora",

author = "Le, \{Tu Cam\} and Yim, \{Chae Yoon\} and Songhee Park and Nikita Katila and Inho Yang and Song, \{Myoung Chong\} and Yoon, \{Yeo Joon\} and Choi, \{Dong Young\} and Hyukjae Choi and Nam, \{Sang Jip\} and William Fenical",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.05.035",

language = "English",

volume = "27",

pages = "3123--3126",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

AU - Le, Tu Cam

AU - Yim, Chae Yoon

AU - Park, Songhee

AU - Katila, Nikita

AU - Yang, Inho

AU - Song, Myoung Chong

AU - Yoon, Yeo Joon

AU - Choi, Dong Young

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2017

Y1 - 2017

N2 - HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

AB - HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

KW - BACE1 inhibitor

KW - Lodopyridone

KW - Marine natural products

KW - Saccharomonospora

UR - https://www.scopus.com/pages/publications/85019930847

U2 - 10.1016/j.bmcl.2017.05.035

DO - 10.1016/j.bmcl.2017.05.035

M3 - Article

C2 - 28539221

AN - SCOPUS:85019930847

SN - 0960-894X

VL - 27

SP - 3123

EP - 3126

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Abstract

Bibliographical note

Keywords

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