Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le, Chae Yoon Yim, Songhee Park, Nikita Katila, Inho Yang, Myoung Chong Song, Yeo Joon Yoon, Dong Young Choi, Hyukjae Choi, Sang Jip Nam, William Fenical

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15 Scopus citations


HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Original languageEnglish
Pages (from-to)3123-3126
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number14
StatePublished - 2017

Bibliographical note

Funding Information:
The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning under grant NRF-2014R1A1A2057302 (to HC) and NRF-2014R1A1A1003492 (to SJN), and by the US National Cancer Institute (NIH) under grant R37 CA044848 (to WF).

Publisher Copyright:
© 2017 Elsevier Ltd


  • BACE1 inhibitor
  • Lodopyridone
  • Marine natural products
  • Saccharomonospora


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