Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le, Chae Yoon Yim, Songhee Park, Nikita Katila, Inho Yang, Myoung Chong Song, Yeo Joon Yoon, Dong Young Choi, Hyukjae Choi, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Original languageEnglish
Pages (from-to)3123-3126
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number14
DOIs
StatePublished - 2017

Keywords

  • BACE1 inhibitor
  • Lodopyridone
  • Marine natural products
  • Saccharomonospora

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