Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le; Chae Yoon Yim; Songhee Park; Nikita Katila; Inho Yang; Myoung Chong Song; Yeo Joon Yoon; Dong Young Choi; Hyukjae Choi; Sang Jip Nam; William Fenical

doi:10.1016/j.bmcl.2017.05.035

Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Tu Cam Le, Chae Yoon Yim, Songhee Park, Nikita Katila, Inho Yang, Myoung Chong Song, Yeo Joon Yoon, Dong Young Choi, Hyukjae Choi, Sang Jip Nam, William Fenical

Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Original language	English
Pages (from-to)	3123-3126
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2017.05.035
State	Published - 2017

Keywords

BACE1 inhibitor
Lodopyridone
Marine natural products
Saccharomonospora

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10.1016/j.bmcl.2017.05.035

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title = "Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.",

abstract = "HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).",

keywords = "BACE1 inhibitor, Lodopyridone, Marine natural products, Saccharomonospora",

author = "Le, {Tu Cam} and Yim, {Chae Yoon} and Songhee Park and Nikita Katila and Inho Yang and Song, {Myoung Chong} and Yoon, {Yeo Joon} and Choi, {Dong Young} and Hyukjae Choi and Nam, {Sang Jip} and William Fenical",

note = "Funding Information: The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning under grant NRF-2014R1A1A2057302 (to HC) and NRF-2014R1A1A1003492 (to SJN), and by the US National Cancer Institute (NIH) under grant R37 CA044848 (to WF). Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.05.035",

language = "English",

volume = "27",

pages = "3123--3126",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "14",

}

TY - JOUR

T1 - Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

AU - Le, Tu Cam

AU - Yim, Chae Yoon

AU - Park, Songhee

AU - Katila, Nikita

AU - Yang, Inho

AU - Song, Myoung Chong

AU - Yoon, Yeo Joon

AU - Choi, Dong Young

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Fenical, William

N1 - Funding Information: The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning under grant NRF-2014R1A1A2057302 (to HC) and NRF-2014R1A1A1003492 (to SJN), and by the US National Cancer Institute (NIH) under grant R37 CA044848 (to WF). Publisher Copyright: © 2017 Elsevier Ltd

PY - 2017

Y1 - 2017

N2 - HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

AB - HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

KW - BACE1 inhibitor

KW - Lodopyridone

KW - Marine natural products

KW - Saccharomonospora

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U2 - 10.1016/j.bmcl.2017.05.035

DO - 10.1016/j.bmcl.2017.05.035

M3 - Article

C2 - 28539221

AN - SCOPUS:85019930847

VL - 27

SP - 3123

EP - 3126

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -

Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

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Keywords

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