Localized 1H-MR spectroscopy in moyamoya disease before and after revascularization surgery

Soo Mee Lim, Hye Young Choi, Jung Soo Suh, Jung Hee Lee, Keun Ho Lim, Dae Chul Suh, Ho Kyu Lee, Tae Hwan Lim, Young Shin Ra

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: To evaluate, using localized proton magnetic resonance spectroscopy (1H-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease. Materials and Methods: Sixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and 99mTc- ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized 1H-MRS, and after revascularization surgery, four patients underwent follow-up 1H-MRS. Results: Decreased NAA/Cr ratios (1.35 ± 0.14 in patients vs. 1.55 ± 0.24 in controls) and Cho/Cr ratios (0.96 ± 0.13 in patients vs. 1.10 ± 0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios. Conclusion: Localized 1H-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, 1H-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalKorean Journal of Radiology
Issue number2
StatePublished - 2003


  • Brain, infarction
  • Magnetic resonance (MR), spectroscopy
  • Moyamoya disease


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