Localization of bcl-2 mRNA in the rabbit central nervous system

Dong Hoon Shin, Hwa Young Lee, Kyung Hoon Lee, Hyun Joon Kim, Wang Jae Lee, Douk Ho Hwang, Sang Ho Baik, Sa Sun Cho

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3 Scopus citations


In this study, we demonstrated bcl-2 expression in the rabbit brain using in situ hybridization and compared the results with the studies done on the other animals. Although the bcl-2 expressions of the rabbit were generally similar to those of the other animals, some differences were also found; the cells in molecular and Purkinje cell layers of the cerebellum, which were bcl-2 negative in the others, showed intense bcl-2 positive signals, while the ependymal cells, arachnoid villi and granular layer, which were positive in the other animals, were not well stained with bcl-2 riboprobes in the rabbit brain. Our findings clearly showed the similarities and differences of rabbit bcl-2 mRNA as compared with the other species for the first time, and provided the basis of further study on the properties of bcl-2 in this species.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalNeuroscience Letters
Issue number1-2
StatePublished - 7 Jan 2000


  • Bcl-2
  • Central nervous system
  • In situ hybridization
  • Rabbit
  • mRNA


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