Local inhibition of Drosophila homeobox-containing neural dorsoventral patterning genes by Dpp

Chun Taek Oh, Seung Hae Kwon, Kyoung Ja Jeon, Pyung Lim Han, Sang Hee Kim, Sang Hak Jeon

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An important step in Drosophila neurogenesis is to establish the neural dorsoventral (DV) patterning. Here we describe how dpp loss-of- and gain-of-function mutation affects the homeobox-containing neural DV patterning genes expressed in the ventral neuroectoderm. Ventral nervous system defective (vnd), intermediate neuroblast defective (ind), muscle-specific homeobox (msh), and orthodenticle (otd) genes participate in development of the central nervous system and peripheral nervous system, and encode homeodomain proteins. otd and msh genes were ectopically expressed in dpp loss-of-function mutation, but vnd and ind were not affected. However, when dpp was ectopically expressed in the ventral neuroectoderm by rho-GAL4/UAS-dpp system, it caused the repression of vnd, and msh expressions in ventral and dorsal columns of the neuroectoderm, respectively, but not that of ind. The later expression pattern of otd was also restricted by Dpp. The expression pattern of msh, vnd and otd in dpp loss-of-function and gain-of-function mutation indicates that Dpp activity does not reach to the ventral midline and it works locally to establish the dorsal boundary of the ventral neuroectoderm.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalFEBS Letters
Issue number3
StatePublished - 20 Nov 2002

Bibliographical note

Funding Information:
We thank Dr. D.M. Mellerick, Dr. C.Q. Doe, and Dr. A. Nose for providing the anti-Vnd antibody, anti-Ind antibody and anti-Msh antibody, respectively. We also thank Seung Jin Kim, Ji Won Kim, Su Na Kim, Gue Chul Hyoun and Jae Kyoung Kim for taking care of flies. This work was supported by the Korea Research Foundation (KRF-99-015-DI0092).


  • Central nervous system
  • Dorsoventral patterning
  • Dpp
  • Drosophila
  • Homeodomain genes


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