Local inhibition of Drosophila homeobox-containing neural dorsoventral patterning genes by Dpp

Chun Taek Oh, Seung Hae Kwon, Kyoung Ja Jeon, Pyung Lim Han, Sang Hee Kim, Sang Hak Jeon

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

An important step in Drosophila neurogenesis is to establish the neural dorsoventral (DV) patterning. Here we describe how dpp loss-of- and gain-of-function mutation affects the homeobox-containing neural DV patterning genes expressed in the ventral neuroectoderm. Ventral nervous system defective (vnd), intermediate neuroblast defective (ind), muscle-specific homeobox (msh), and orthodenticle (otd) genes participate in development of the central nervous system and peripheral nervous system, and encode homeodomain proteins. otd and msh genes were ectopically expressed in dpp loss-of-function mutation, but vnd and ind were not affected. However, when dpp was ectopically expressed in the ventral neuroectoderm by rho-GAL4/UAS-dpp system, it caused the repression of vnd, and msh expressions in ventral and dorsal columns of the neuroectoderm, respectively, but not that of ind. The later expression pattern of otd was also restricted by Dpp. The expression pattern of msh, vnd and otd in dpp loss-of-function and gain-of-function mutation indicates that Dpp activity does not reach to the ventral midline and it works locally to establish the dorsal boundary of the ventral neuroectoderm.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalFEBS Letters
Volume531
Issue number3
DOIs
StatePublished - 20 Nov 2002

Keywords

  • Central nervous system
  • Dorsoventral patterning
  • Dpp
  • Drosophila
  • Homeodomain genes

Fingerprint

Dive into the research topics of 'Local inhibition of Drosophila homeobox-containing neural dorsoventral patterning genes by Dpp'. Together they form a unique fingerprint.

Cite this