Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)

Jong Sang Park, Yong Beom Lim, Young Min Kvvon, Byeongmoon Jeong, Young Hun Choi, Sung Wan Kim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.

Original languageEnglish
Pages (from-to)2305-2309
Number of pages5
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume37
Issue number14
DOIs
StatePublished - 15 Jul 1999

Keywords

  • Liposome
  • Membrane fusion
  • Ph-sensitive polymer
  • Resonance energy transfer

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