Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)

Jong Sang Park; Yong Beom Lim; Young Min Kvvon; Byeongmoon Jeong; Young Hun Choi; Sung Wan Kim

doi:10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5

Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)

Jong Sang Park, Yong Beom Lim, Young Min Kvvon, Byeongmoon Jeong, Young Hun Choi, Sung Wan Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.

Original language	English
Pages (from-to)	2305-2309
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	37
Issue number	14
DOIs	https://doi.org/10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5
State	Published - 15 Jul 1999

Keywords

Liposome
Membrane fusion
Ph-sensitive polymer
Resonance energy transfer

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10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5

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title = "Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)",

abstract = "Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.",

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T1 - Liposome fusion induced by pH-sensitive copolymer

T2 - Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)

AU - Park, Jong Sang

AU - Lim, Yong Beom

AU - Kvvon, Young Min

AU - Jeong, Byeongmoon

AU - Choi, Young Hun

AU - Kim, Sung Wan

PY - 1999/7/15

Y1 - 1999/7/15

N2 - Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.

AB - Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.

KW - Liposome

KW - Membrane fusion

KW - Ph-sensitive polymer

KW - Resonance energy transfer

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U2 - 10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5

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IS - 14

ER -

Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)

Abstract

Keywords

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