Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation

Youngae Jung, Youngjin Cho, Nami Kim, Il Young Oh, Sang Won Kang, Eue Keun Choi, Geum Sook Hwang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its incidence is increasing worldwide. One method used to restore sinus rhythm is direct current cardioversion (DCCV). Despite the high success rate of DCCV, AF typically recurs within the first 2 weeks. However, our understanding of the pathophysiology of AF recurrence, incidence, and progression are highly limited. Lipidomic profiling was applied to identify altered lipids in plasma from patients with AF using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis. Partial least-squares discriminant analysis revealed a clear separation between AF patients and healthy controls. The levels of several lipid species, including fatty acids and phospholipids, were different between AF patients and healthy controls, indicating that oxidative stress and inflammation are associated with the pathogenesis of AF. Similar patterns were also detected between recurrent and non-recurrent AF patients. These results suggest that the elevated saturated fatty acid and reduced polyunsaturated fatty acid levels in AF patients may be associated with enhanced inflammation and that free fatty acid levels may play a crucial role in the development and progression of AF.

Original languageEnglish
Article numbere0196709
JournalPLoS ONE
Issue number5
StatePublished - May 2018

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation (NRF) of Korea (no. 2013M3A9B6046418 and 2017M3A9D5A01052449), and the National Research Council of Science and Technology (DRC-14-3-KBSI and CAP-2012-2-KBSI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2018 Jung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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