Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells

Jieun Yun, Bo Geun Kim, Jong Soon Kang, Song Kyu Park, Kiho Lee, Dong Hoon Hyun, Hwan Mook Kim, Man Jin In, Dong Chung Kim

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 μg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalJournal of Medicinal Food
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 2015

Keywords

  • cancer invasion
  • lipid-soluble ginseng extract
  • lung metastasis
  • matrix metalloprotease-2

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