Ligand effects in rhodium complexes for chemical NADH regeneration

Pegah Tavakoli Fard, Kayoung Kim, Sohyun Lee, Jinheung Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Various (pentamethylcyclopentadienyl)-rhodium(III) complexes comprising aromatic bidentate ligands [(Cp*)Rh(L)Cl]+ (Cp* = pentamethylcyclopentadienyl, L = 2,2′-bipyridine, 1,10-phenanthroline, and their derivatives) were prepared to compare their reactivities of chemical cofactor regeneration. When the catalytic NADH regeneration was performed with sodium formate, the reaction rates were compared with six Rh(III) complexes. The kinetics of the reactions including kinetic isotope effects are also studied in the chemical NADH regeneration. The Rh(III) complexes react with formate efficiently to afford the intermediates [(Cp*)Rh(L)(H)]+ and CO2. The electronic and steric effects of the ligands of the Rh complexes were observed on the reaction rates. The overall reaction rates of the NADH regeneration were also obtained using DCOO in H2O. Such H/D exchange rates of [(Cp*)Rh(L)(H)]+ and the observation of a deuterium kinetic isotope provide valuable mechanistic insight into the catalytic NADH regeneration.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume43
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • cofactor regeneration
  • formate
  • kinetic isotope effect
  • ligand effect
  • rhodium complex

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