Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: Differing contributions of ALOX5 polymorphism in Korean population

Seung Hyun Kim, Jeong Hee Choi, J. W. Holloway, Chang Hee Suh, Dong Ho Nahm, Eun Ho Ha, Choon Sik Park, Hae Sim Park

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Abstract

The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This is supported by evidence that cyclooxygenase 2 inhibitor is given safely to patients with AIU. The present study was designed to investigate the role of genetic polymorphism of LT related genes in the pathogenesis of AIU via a case-control study. We screened single nucleotide polymorphisms (SNPs) in genes encoding enzymes involved in leukotriene synthesis in the Korean population with AIU (n=101), ASA-intolerant asthma (AIA, n=95) and normal healthy controls (n=123). Genotype was determined by primer extension reactions using the SNapShot ddNTP primer extension kit. Among 8 SNPs of four LT related genes, the polymorphism of ALOX5 at positions of -1708 G>A showed significant difference in genotype frequency between AIU and AIA (p=0.01). Furthermore, there were significant differences observed in the frequencies of two ALOX5 haplotypes between the AIU group and AIA group (p<0.05). However, there were no differences in allele, genotype, or haplotype frequencies of ALOX5 between the AIU group and the normal control group. These results suggested that ALOX5 has a differing contribution in two major clinical pathogenesis related to ASA-sensitivity.

Original languageEnglish
Pages (from-to)926-931
Number of pages6
JournalJournal of Korean Medical Science
Volume20
Issue number6
DOIs
StatePublished - Dec 2005

Keywords

  • Aspirin, Hypersensitivity
  • Leukotrienes
  • Polymorphism, Genetic
  • Urticaria

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