Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: A prospective feasibility study

Jin Woo Kim, Sun Jong Kim, Myung Rae Kim

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68 Scopus citations

Abstract

Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p = 0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.

Original languageEnglish
Pages (from-to)854-859
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume52
Issue number9
DOIs
StatePublished - 1 Nov 2014

Bibliographical note

Funding Information:
This study was supported by the Ewha Global Top5 Grant 2013 of the Ewha Womans University, Seoul, Korea. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

Publisher Copyright:
© 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Keywords

  • Bisphosphonate
  • Growth factor
  • Osteonecrosis of the jaw
  • Platelet concentrate
  • Platelet-rich fibrin

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