Abstract
Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p = 0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.
| Original language | English |
|---|---|
| Pages (from-to) | 854-859 |
| Number of pages | 6 |
| Journal | British Journal of Oral and Maxillofacial Surgery |
| Volume | 52 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1 Nov 2014 |
Bibliographical note
Publisher Copyright:© 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Keywords
- Bisphosphonate
- Growth factor
- Osteonecrosis of the jaw
- Platelet concentrate
- Platelet-rich fibrin