Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: A prospective feasibility study

Jin Woo Kim, Sun Jong Kim, Myung Rae Kim

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52 Scopus citations

Abstract

Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p = 0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.

Original languageEnglish
Pages (from-to)854-859
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume52
Issue number9
DOIs
StatePublished - 1 Nov 2014

Keywords

  • Bisphosphonate
  • Growth factor
  • Osteonecrosis of the jaw
  • Platelet concentrate
  • Platelet-rich fibrin

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