Leptin as a potential target for estrogen receptor-positive breast cancer

Cha Kyong Yom, Kyung Min Lee, Wonshik Han, Sung Won Kim, Hee Sung Kim, Byung In Moon, Ku Young Jeong, Seock Ah Im, Dong Young Noh

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Purpose: Leptin is a potent adipokine that plays a significant role in tumor development and the progression of breast cancer. The aim of this study was to evaluate whether leptin affects the response to tamoxifen treatment in estrogen receptor (ER)-positive breast cancer cells. Methods: Leptin, leptin receptor (Ob-R), and activation of signaling pathways were studied by Western immunoblotting. The effects of leptin on tamoxifen-dependent growth inhibition were studied in MCF-7 and T-47D cells. Results: Leptin was expressed in MCF-7 and T-47D and had a proliferative effect on MCF-7 cells. Leptin significantly inhibited the antiestrogenic effect of tamoxifen in both cells only under β-estradiol (E2) (20 nM) conditions. In MCF-7, the inhibitory effect against tamoxifen was a result from the activation of the ERK1/2 and STAT3 signal transduction pathway. Conclusion: Leptin interferes with the effects of tamoxifen under E2 stimulated conditions in ER-positive breast cancer cells. These results imply that inhibition of leptin is expected to enhance the response to tamoxifen in ER-positive breast cancer cells, and, therefore, could be a promising way to overcome endocrine resistance.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalJournal of Breast Cancer
Volume16
Issue number2
DOIs
StatePublished - Jun 2013

Keywords

  • Breast neoplasms
  • Hormone resistance
  • Leptin

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