Left ventricular response after cardiac resynchronization therapy is related to early left atrial volume reduction

In Jeong Cho, Jae Sun Uhm, Jaewon Oh, Jong Ho Nam, Hee Tae Yu, Taehoon Kim, Boyoung Joung, Seok Min Kang

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1 Scopus citations


Background/Aims: The current study aimed to elucidate a time-course change in left atrial volume after cardiac resynchronization therapy (CRT) and to verify factors associated with left atrial volume reduction (LAVR) and its prognostic im-plications. Methods: The records of 97 patients were retrospectively reviewed after CRT. Echocardiographic data were analyzed at baseline before CRT, at early follow-up (FU) (≤ 1 year, median 6 months), and at late FU (median 30 months). Left ventricular volume response (LVVR) was defined as 15% reduction in left ventricular (LV) end-systolic volume (ESV). LAVR was classified into two groups by the median value at early FU: LAVR (≥ 7.5%) and no LAVR (< 7.5%). Results: LV ESV index continuously decreased from baseline to early FU and from early FU to late FU (106.1 ± 47.4 mL/m2 vs. 87.6 ± 51.6 mL/m2 vs. 72.5 ± 57.1 mL/m2). LA volume index decreased from baseline to early FU, but there were no reduc-tions thereafter (51.8 ± 21.9 mL/m2 vs. 45.1 ± 19.6 mL/m2 vs. 44.9 ± 23.0 mL/m2). The only echocardiographic factor associated with LAVR was change in E velocity (odds ratio [OR], 1.04; p = 0.002). Early LAVR (OR, 10.05; p = 0.002) was an independent predictor for late LVVR. Conclusions: LAVR was related to reduction in E velocity, suggesting its relation with optimization of LV filling pressure. Early LAVR was a predictor for LVVR to CRT in long-term FU.

Original languageEnglish
Pages (from-to)1125-1135
Number of pages11
JournalKorean Journal of Internal Medicine
Issue number5
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Korean Association of Internal Medicine.


  • Atrial remodeling
  • Cardiac resynchronization therapy
  • Ventricular remodeling


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