Left atrial volume index is an independent predictor of hypertensive response to exercise in patients with hypertension

Sang Eun Lee, Jong Chan Youn, Hye Sun Lee, Sungha Park, Sang Hak Lee, In Jeong Cho, Chi Young Shim, Geu Ru Hong, Donghoon Choi, Seok Min Kang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A hypertensive response to exercise (HRE) is known to be associated with higher risk of heart failure and future cardiovascular events in patients with hypertension. Left atrial volume index (LAVI) is associated with the diastolic dysfunction, indicating exercise intolerance. Therefore, we investigated whether LAVI is relevant to HRE during cardiopulmonary exercise test (CPET). We studied 118 consecutive hypertensive patients (61 men, 57±11 years) and 45 normotensive control subjects (16 men, 54±8 years). Clinical characteristics, CPET, echocardiographic and laboratory findings were assessed at the time of enrollment. HRE was defined as maximum systolic blood pressure (SBP)≥210 mm Hg in men and ≥190 mm Hg in women. HRE was more prevalent in hypertensive patients compared with normotensive control subjects (50.8% vs. 20.0%, P<0.001). Age and baseline SBP were shown to be associated with HRE in normotensive control subjects, as were baseline SBP and LAVI in hypertensive group. In multivariate analysis, LAVI was found to be an independent predictor of HRE in hypertensive patients (P=0.020) but not in normotensive control subjects (P=0.936) when controlled for age, sex, body mass index and peak oxygen consumption. Higher LAVI, reflecting the duration and severity of increased left atrial pressure is independently associated with HRE in hypertensive patients, but not in normotensive control subjects.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalHypertension Research
Issue number2
StatePublished - 7 Feb 2015

Bibliographical note

Publisher Copyright:
© 2015 The Japanese Society of Hypertension All rights reserved.


  • Cardiopulmonary exercise test
  • hypertensive response to exercise
  • left atrial volume index


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