Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Joohee Kim; Jae Moon Yun; Mi Kyung Kim; Oran Kwon; Belong Cho

doi:10.1089/jmf.2017.3937

Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Joohee Kim, Jae Moon Yun, Mi Kyung Kim, Oran Kwon, Belong Cho

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Lactobacillus gasseri BNR17 is a probiotic strain isolated from human breast milk. Animal studies reported that BNR17 inhibited increases in body weight and adipose tissue weights. The purpose of this study was to evaluate the antiobesity effects of BNR17 in humans. In a randomized, double-blind, placebo-controlled trial, 90 volunteers aged 20-75 years with body mass index (BMI) from 25 to 35 kg/m² were randomized to receive a placebo, low-dose BNR (BNR-L, 10⁹ CFU/day), or high-dose BNR (BNR-H, 10¹⁰ CFU/day) for 12 weeks. Body weight, BMI, waist and hip circumferences, waist-to-hip ratio, abdominal adipose tissue areas, body fat mass, lean body mass, and biochemical parameters were assessed at the beginning and end of the trial. Visceral adipose tissue (VAT) was significantly decreased in the BNR-H group compared with the placebo group (P = .038). Difference of VAT areas of the BNR-H group compared with the placebo group after 12-week consumption of BNR17 was significant (-21.6 cm², P = .012). Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P = .045 and .012, respectively) compared with the baseline values, but not in the placebo group. Biochemical parameters were not significantly different among the groups. These findings suggest that daily consumption of BNR17 may contribute to reduced visceral fat mass in obese adults.

Original language	English
Pages (from-to)	454-461
Number of pages	8
Journal	Journal of Medicinal Food
Volume	21
Issue number	5
DOIs	https://doi.org/10.1089/jmf.2017.3937
State	Published - May 2018

Bibliographical note

Funding Information:
We are grateful to the participants in this study. This study was supported by the ‘‘Food Functionality Evaluation Program’’ under the Ministry of Food, Agriculture, Forestry and Fisheries and was partially supported by the Korea Food Research Institute and Bioneer Corporation. It was also supported by the Ministry of Science, ICT & Future Planning (NRF 2012 M3A9C4048761). The funding sources had no involvement in the design, collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit this article for publication.

Publisher Copyright:
Copyright © 2018, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2018.

Keywords

body weight
Lactobacillus gasseri
obesity
probiotics
visceral adipose tissue

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/jmf.2017.3937

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title = "Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial",

abstract = "Lactobacillus gasseri BNR17 is a probiotic strain isolated from human breast milk. Animal studies reported that BNR17 inhibited increases in body weight and adipose tissue weights. The purpose of this study was to evaluate the antiobesity effects of BNR17 in humans. In a randomized, double-blind, placebo-controlled trial, 90 volunteers aged 20-75 years with body mass index (BMI) from 25 to 35 kg/m2 were randomized to receive a placebo, low-dose BNR (BNR-L, 109 CFU/day), or high-dose BNR (BNR-H, 1010 CFU/day) for 12 weeks. Body weight, BMI, waist and hip circumferences, waist-to-hip ratio, abdominal adipose tissue areas, body fat mass, lean body mass, and biochemical parameters were assessed at the beginning and end of the trial. Visceral adipose tissue (VAT) was significantly decreased in the BNR-H group compared with the placebo group (P = .038). Difference of VAT areas of the BNR-H group compared with the placebo group after 12-week consumption of BNR17 was significant (-21.6 cm2, P = .012). Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P = .045 and .012, respectively) compared with the baseline values, but not in the placebo group. Biochemical parameters were not significantly different among the groups. These findings suggest that daily consumption of BNR17 may contribute to reduced visceral fat mass in obese adults.",

keywords = "body weight, Lactobacillus gasseri, obesity, probiotics, visceral adipose tissue",

author = "Joohee Kim and Yun, {Jae Moon} and Kim, {Mi Kyung} and Oran Kwon and Belong Cho",

note = "Funding Information: We are grateful to the participants in this study. This study was supported by the {\textquoteleft}{\textquoteleft}Food Functionality Evaluation Program{\textquoteright}{\textquoteright} under the Ministry of Food, Agriculture, Forestry and Fisheries and was partially supported by the Korea Food Research Institute and Bioneer Corporation. It was also supported by the Ministry of Science, ICT & Future Planning (NRF 2012 M3A9C4048761). The funding sources had no involvement in the design, collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit this article for publication. Publisher Copyright: Copyright {\textcopyright} 2018, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2018.",

year = "2018",

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AU - Yun, Jae Moon

AU - Kim, Mi Kyung

AU - Kwon, Oran

AU - Cho, Belong

N1 - Funding Information: We are grateful to the participants in this study. This study was supported by the ‘‘Food Functionality Evaluation Program’’ under the Ministry of Food, Agriculture, Forestry and Fisheries and was partially supported by the Korea Food Research Institute and Bioneer Corporation. It was also supported by the Ministry of Science, ICT & Future Planning (NRF 2012 M3A9C4048761). The funding sources had no involvement in the design, collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit this article for publication. Publisher Copyright: Copyright © 2018, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2018.

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N2 - Lactobacillus gasseri BNR17 is a probiotic strain isolated from human breast milk. Animal studies reported that BNR17 inhibited increases in body weight and adipose tissue weights. The purpose of this study was to evaluate the antiobesity effects of BNR17 in humans. In a randomized, double-blind, placebo-controlled trial, 90 volunteers aged 20-75 years with body mass index (BMI) from 25 to 35 kg/m2 were randomized to receive a placebo, low-dose BNR (BNR-L, 109 CFU/day), or high-dose BNR (BNR-H, 1010 CFU/day) for 12 weeks. Body weight, BMI, waist and hip circumferences, waist-to-hip ratio, abdominal adipose tissue areas, body fat mass, lean body mass, and biochemical parameters were assessed at the beginning and end of the trial. Visceral adipose tissue (VAT) was significantly decreased in the BNR-H group compared with the placebo group (P = .038). Difference of VAT areas of the BNR-H group compared with the placebo group after 12-week consumption of BNR17 was significant (-21.6 cm2, P = .012). Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P = .045 and .012, respectively) compared with the baseline values, but not in the placebo group. Biochemical parameters were not significantly different among the groups. These findings suggest that daily consumption of BNR17 may contribute to reduced visceral fat mass in obese adults.

AB - Lactobacillus gasseri BNR17 is a probiotic strain isolated from human breast milk. Animal studies reported that BNR17 inhibited increases in body weight and adipose tissue weights. The purpose of this study was to evaluate the antiobesity effects of BNR17 in humans. In a randomized, double-blind, placebo-controlled trial, 90 volunteers aged 20-75 years with body mass index (BMI) from 25 to 35 kg/m2 were randomized to receive a placebo, low-dose BNR (BNR-L, 109 CFU/day), or high-dose BNR (BNR-H, 1010 CFU/day) for 12 weeks. Body weight, BMI, waist and hip circumferences, waist-to-hip ratio, abdominal adipose tissue areas, body fat mass, lean body mass, and biochemical parameters were assessed at the beginning and end of the trial. Visceral adipose tissue (VAT) was significantly decreased in the BNR-H group compared with the placebo group (P = .038). Difference of VAT areas of the BNR-H group compared with the placebo group after 12-week consumption of BNR17 was significant (-21.6 cm2, P = .012). Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P = .045 and .012, respectively) compared with the baseline values, but not in the placebo group. Biochemical parameters were not significantly different among the groups. These findings suggest that daily consumption of BNR17 may contribute to reduced visceral fat mass in obese adults.

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Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract

Bibliographical note

Keywords

UN SDGs

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