Lack of association between the Klotho gene and COPD

Woo Jin Kim, Yeon Mok Oh, Tae Hyung Kim, Ji Hyun Lee, Eun Kyung Kim, Jin Hwa Lee, Sang Min Lee, Tae Rim Shin, Ho Il Yoon, Seong Yong Lim, Sang Do Lee

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1 Scopus citations


Background: Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity. Methods: A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear, regression was performed to investigate their association with emphysema severity in COPD subjects. Results: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity. Conclusion: Genetic polymorphisms of the klotlto gene were not associated with COPD in a Korean population. Copyright

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalTuberculosis and Respiratory Diseases
Issue number4
StatePublished - Oct 2011


  • Chronic obstructive
  • Genetic
  • Polymorphism
  • Pulmonary disease


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