TY - JOUR
T1 - Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters
T2 - A DMET Plus microarray assessment
AU - Yi, Sojeong
AU - An, Hyungmi
AU - Lee, Howard
AU - Lee, Sangin
AU - Ieiri, Ichiro
AU - Lee, Youngjo
AU - Cho, Joo Youn
AU - Hirota, Takeshi
AU - Fukae, Masato
AU - Yoshida, Kenji
AU - Nagatsuka, Shinichiro
AU - Kimura, Miyuki
AU - Irie, Shin
AU - Sugiyama, Yuichi
AU - Shin, Dong Wan
AU - Lim, Kyoung Soo
AU - Chung, Jae Yong
AU - Yu, Kyung Sang
AU - Jang, In Jin
N1 - Publisher Copyright:
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
PY - 2014/10/10
Y1 - 2014/10/10
N2 - Results: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.
AB - Results: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.
KW - Drug-metabolizing enzymes and transporters microarray
KW - East Asian
KW - Ethnic difference
KW - Pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=84916196118&partnerID=8YFLogxK
U2 - 10.1097/FPC.0000000000000075
DO - 10.1097/FPC.0000000000000075
M3 - Article
C2 - 25029633
AN - SCOPUS:84916196118
SN - 1744-6872
VL - 24
SP - 477
EP - 485
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
IS - 10
ER -