Kinetic analysis of the MAPK and PI3K/Akt signaling pathways

C. V. Suresh Babu, Sheikh Md Enayetul Babar, Eun Joo Song, Eulsik Oh, Young Sook Yoo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3′-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.

Original languageEnglish
Pages (from-to)397-406
Number of pages10
JournalMolecules and Cells
Issue number3
StatePublished - 31 May 2008


  • Biochemical pathway
  • Computational modeling
  • MAPK
  • PI3K/Akt
  • Signal transduction
  • Systems biology


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