Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice

Eunkyo Park, Kwangseok Hong, Byoung Mog Kwon, Yuri Kim, Jung Hyun Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Emerging evidence has shown that flavonoids extracted from Artemisia have beneficial effects on metabolic disorders. However, whether and how jaceosidin ameliorates insulin resistance and diabetic nephropathy in type 2 diabetes mellitus is largely unknown. For 8 weeks, db/db diabetic mice were fed with or without jaceosidin. Oral jaceosidin supplementation reduced fasting blood glucose levels and insulin resistance through the upregulation of insulin receptor downstream pathways in the liver and skeletal muscles. While jaceosidin did not noticeably alter kidney filtration function, this dietary intervention contributed to attenuating the accumulation of advanced glycation end products in diabetic kidneys. The levels of VEGF-a (vascular endothelial growth factor-a) proteins in the diabetic kidneys were markedly diminished by jaceosidin treatments, which increased the expression and activity of Cu (copper) and Zn-SOD (zinc-superoxide dismutase). Therefore, it is suggested that jaceosidin supplementation elicits antidiabetic effects and treats diabetic nephropathy by augmenting insulin signaling, suppressing fibrosis, and enhancing antioxidant activity.

Original languageEnglish
Pages (from-to)1083-1092
Number of pages10
JournalJournal of Medicinal Food
Volume23
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Akt
  • Diabetic nephropathy
  • Glucose transporter
  • Jaceosidin
  • Superoxide dismutase

Fingerprint

Dive into the research topics of 'Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice'. Together they form a unique fingerprint.

Cite this