Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori

D. H. Kwon, J. J. Kim, M. Lee, Y. Yamaoka, M. Kato, M. S. Osato, F. A.K. El-Zaatari, D. Y. Graham

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 μg/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.

Original languageEnglish
Pages (from-to)3203-3205
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number11
DOIs
StatePublished - 2000

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