Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing

Jaesang Kim, Bradley W. Jones, Christiane Zock, Zhoufeng Chen, Hai Wang, Corey S. Goodman, David J. Anderson

Research output: Contribution to journalArticlepeer-review

162 Scopus citations

Abstract

The glial cells missing (gcm) gene in Drosophila encodes a transcription factor that determines the choice between glial and neuronal fates. We report here the isolation of two mammalian gcm homologs, Gcm1 and Gcm2, and the characterization of their expression patterns during embryonic development. Although Gcm2 is expressed in neural tissues at a low level, the major sites of expression for both of the mammalian genes are nonneural, suggesting that the functions of the mammalian homologs have diverged and diversified. However, when expressed ectopically, Gcm1 can substitute functionally for Drosophila gcm by transforming presumptive neurons into glia. Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family.

Original languageEnglish
Pages (from-to)12364-12369
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number21
DOIs
StatePublished - 13 Oct 1998

Fingerprint

Dive into the research topics of 'Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing'. Together they form a unique fingerprint.

Cite this